Package: glyclean 0.14.1

Bin Fu

glyclean: Perform Preprocessing on Glycomics and Glycoproteomics Data

Provides comprehensive data preprocessing tools for glycomics and glycoproteomics experiments. The package offers both automated and manual preprocessing pipelines, including normalization (median, quantile, vsn, total area), missing value handling (filtering, imputation using various methods), batch effect correction (using ComBat and other methods), data aggregation (at peptide, glycan, or site level), and quality control functions. The automated pipeline intelligently selects appropriate methods based on data characteristics and sample size, making it easy to prepare clean, analysis-ready data for downstream statistical analysis within the glycoverse ecosystem. Works seamlessly with 'glyexp::experiment()' objects to ensure data consistency and interoperability.

Authors:Bin Fu [aut, cre]

glyclean_0.14.1.tar.gz
glyclean_0.14.1.zip(r-4.7)glyclean_0.14.1.zip(r-4.6)glyclean_0.14.1.zip(r-4.5)
glyclean_0.14.1.tgz(r-4.6-any)glyclean_0.14.1.tgz(r-4.5-any)
glyclean_0.14.1.tar.gz(r-4.7-any)glyclean_0.14.1.tar.gz(r-4.6-any)
glyclean_0.14.1.tgz(r-4.6-emscripten)
manual.pdf |manual.html
card.svg |card.png
glyclean/json (API)
NEWS

# Install 'glyclean' in R:
install.packages('glyclean', repos = c('https://glycoverse.r-universe.dev', 'https://cloud.r-project.org'))

Bug tracker:https://github.com/glycoverse/glyclean/issues

Pkgdown/docs site:https://glycoverse.github.io

On CRAN:

Conda:

4.96 score 1 packages 21 scripts 49 exports 123 dependencies

Last updated from:d10d13d69b (on v0.14.1). Checks:9 OK. Indexed: yes.

TargetResultTimeFilesSyslog
linux-devel-x86_64OK252
source / vignettesOK400
linux-release-x86_64OK256
macos-release-arm64OK127
macos-oldrel-arm64OK116
windows-develOK186
windows-releaseOK202
windows-oldrelOK170
wasm-releaseOK178

Exports:add_site_seqadjust_proteinaggregateauto_aggregateauto_cleanauto_codaauto_correct_batch_effectauto_imputeauto_normalizeauto_removecorrect_batch_effectdetect_batch_effectimpute_bpcaimpute_fw_knnimpute_half_sample_minimpute_min_probimpute_miss_forestimpute_ppcaimpute_sample_minimpute_svdimpute_sw_knnimpute_zeronormalize_loesscycnormalize_loessfnormalize_mediannormalize_median_absnormalize_median_quotientnormalize_quantilenormalize_rlrnormalize_rlrmanormalize_rlrmacycnormalize_total_areanormalize_vsnplot_batch_pcaplot_cv_dentplot_int_boxplotplot_missing_barplot_missing_heatmapplot_rank_abundanceplot_rep_scatterplot_rleplot_tic_barremove_constantremove_low_cvremove_low_exprremove_low_varremove_raretransform_alrtransform_clr

Dependencies:ade4annotateAnnotationDbiaskpassbackportsBHBiobaseBiocBaseUtilsBiocFileCacheBiocGenericsBiocParallelBiostringsbitbit64blobcachemcheckmateclicodetoolscpp11crayoncurlDBIdbplyrdigestdoRNGdplyredgeRfarverfastmapfilelockforcatsforeachformatRfurrrfutile.loggerfutile.optionsfuturegenefiltergenericsggplot2globalsglueglyexpglyreprgtablehmshttrhttr2igraphIRangesisobanditeratorsitertoolsjsonliteKEGGRESTlabelinglambda.rlatticelifecyclelimmalistenvlocfitmagrittrMASSMatrixMatrixGenericsmatrixStatsmemoisemgcvmimemissForestnlmeopensslparallellypcaMethodspillarpixmappkgconfigpngprettyunitsprogresspurrrR6randomForestrangerrappdirsrbibutilsRColorBrewerRcppRcppArmadilloRcppEigenRdpackrjsonconsrlangrngtoolsRSQLiterstackdequeS4VectorsS7scalessegmentedSeqinfoseqinrsnowspstatmodstringistringrsurvivalsvasystibbletidyrtidyselectUniProt.wsutf8vctrsviridisLitewithrXMLxtableXVector

Get Started with glyclean

Rendered fromglyclean.Rmdusingknitr::rmarkdownon Jun 17 2026.

Last update: 2026-05-05
Started: 2025-06-17

Readme and manuals

Help Manual

Help pageTopics
Add site-specific sequence information.add_site_seq add_site_seq.default add_site_seq.glyexp_experiment
Adjust Protein Expressionadjust_protein adjust_protein.default adjust_protein.glyexp_experiment
Aggregate Dataaggregate glyclean_aggregate.default glyclean_aggregate.glyexp_experiment
Automatic Aggregationauto_aggregate
Automatic Data Preprocessingauto_clean
Automatical CoDA transformationauto_coda
Automatic Batch Correctionauto_correct_batch_effect
Automatic Imputationauto_impute
Automatic Normalizationauto_normalize
Automatic Removing Variablesauto_remove
Correct Batch Effectcorrect_batch_effect correct_batch_effect.default correct_batch_effect.glyexp_experiment correct_batch_effect.matrix
Detect batch effectdetect_batch_effect detect_batch_effect.default detect_batch_effect.glyexp_experiment detect_batch_effect.matrix
BPCA Imputationimpute_bpca impute_bpca.default impute_bpca.glyexp_experiment impute_bpca.matrix
Feature-wise KNN Imputationimpute_fw_knn impute_fw_knn.default impute_fw_knn.glyexp_experiment impute_fw_knn.matrix
Half Sample Minimum Imputationimpute_half_sample_min impute_half_sample_min.default impute_half_sample_min.glyexp_experiment impute_half_sample_min.matrix
Minimum Probability Imputationimpute_min_prob impute_min_prob.default impute_min_prob.glyexp_experiment impute_min_prob.matrix
MissForest Imputationimpute_miss_forest impute_miss_forest.default impute_miss_forest.glyexp_experiment impute_miss_forest.matrix
PPCA Imputationimpute_ppca impute_ppca.default impute_ppca.glyexp_experiment impute_ppca.matrix
Sample Minimum Imputationimpute_sample_min impute_sample_min.default impute_sample_min.glyexp_experiment impute_sample_min.matrix
SVD Imputationimpute_svd impute_svd.default impute_svd.glyexp_experiment impute_svd.matrix
Sample-wise KNN Imputationimpute_sw_knn impute_sw_knn.default impute_sw_knn.glyexp_experiment impute_sw_knn.matrix
Zero Imputationimpute_zero impute_zero.default impute_zero.glyexp_experiment impute_zero.matrix
LoessCyc Normalizationnormalize_loesscyc normalize_loesscyc.default normalize_loesscyc.glyexp_experiment normalize_loesscyc.matrix
LoessF Normalizationnormalize_loessf normalize_loessf.default normalize_loessf.glyexp_experiment normalize_loessf.matrix
Median Normalizationnormalize_median normalize_median.default normalize_median.glyexp_experiment normalize_median.matrix
Absolute Median Normalizationnormalize_median_abs normalize_median_abs.default normalize_median_abs.glyexp_experiment normalize_median_abs.matrix
Median Quotient Normalizationnormalize_median_quotient normalize_median_quotient.default normalize_median_quotient.glyexp_experiment normalize_median_quotient.matrix
Quantile Normalizationnormalize_quantile normalize_quantile.default normalize_quantile.glyexp_experiment normalize_quantile.matrix
Robust Linear Regression Normalizationnormalize_rlr normalize_rlr.default normalize_rlr.glyexp_experiment normalize_rlr.matrix
Robust Linear Regression with Median Adjustment Normalizationnormalize_rlrma normalize_rlrma.default normalize_rlrma.glyexp_experiment normalize_rlrma.matrix
Robust Linear Regression with Median Adjustment and Cyclic Normalizationnormalize_rlrmacyc normalize_rlrmacyc.default normalize_rlrmacyc.glyexp_experiment normalize_rlrmacyc.matrix
Total Area Normalizationnormalize_total_area normalize_total_area.default normalize_total_area.glyexp_experiment normalize_total_area.matrix
Variance Stabilizing Normalizationnormalize_vsn normalize_vsn.default normalize_vsn.glyexp_experiment normalize_vsn.matrix
Plot PCA Score by Batchplot_batch_pca
Plot CV Densityplot_cv_dent
Plot Log-Intensity Boxplots by Sampleplot_int_boxplot
Plot Missing Value Proportions by Sample or Variableplot_missing_bar
Plot Missing Value Heatmapplot_missing_heatmap
Plot Rank Abundanceplot_rank_abundance
Plot Replicate Scatter Plotsplot_rep_scatter
Plot Relative Log Expression (RLE) Boxplotsplot_rle
Plot Total Intensity by Sampleplot_tic_bar
Remove Constant Variablesremove_constant
Remove Variables with Low Coefficient of Variationremove_low_cv remove_low_cv.default remove_low_cv.glyexp_experiment remove_low_cv.matrix
Remove Variables with Low Expressionremove_low_expr remove_low_expr.default remove_low_expr.glyexp_experiment remove_low_expr.matrix
Remove Variables with Low Variance Remove Variables with Low Varianceremove_low_var remove_low_var.default remove_low_var.glyexp_experiment remove_low_var.matrix
Remove Rare Variables with Too Many Missing Valuesremove_rare remove_rare.default remove_rare.glyexp_experiment remove_rare.matrix
Additive Log-Ratio Transformationtransform_alr transform_alr.default transform_alr.glyexp_experiment transform_alr.matrix
Centered Log-Ratio Transformationtransform_clr transform_clr.default transform_clr.glyexp_experiment transform_clr.matrix