Package: glyclean 0.14.1


Bin Fu
glyclean: Perform Preprocessing on Glycomics and Glycoproteomics Data
Provides comprehensive data preprocessing tools for glycomics and glycoproteomics experiments. The package offers both automated and manual preprocessing pipelines, including normalization (median, quantile, vsn, total area), missing value handling (filtering, imputation using various methods), batch effect correction (using ComBat and other methods), data aggregation (at peptide, glycan, or site level), and quality control functions. The automated pipeline intelligently selects appropriate methods based on data characteristics and sample size, making it easy to prepare clean, analysis-ready data for downstream statistical analysis within the glycoverse ecosystem. Works seamlessly with 'glyexp::experiment()' objects to ensure data consistency and interoperability.
Authors:
glyclean_0.14.1.tar.gz
glyclean_0.14.1.zip(r-4.7)glyclean_0.14.1.zip(r-4.6)glyclean_0.14.1.zip(r-4.5)
glyclean_0.14.1.tgz(r-4.6-any)glyclean_0.14.1.tgz(r-4.5-any)
glyclean_0.14.1.tar.gz(r-4.7-any)glyclean_0.14.1.tar.gz(r-4.6-any)
glyclean_0.14.1.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
card.svg |card.png
glyclean/json (API)
NEWS
| # Install 'glyclean' in R: |
| install.packages('glyclean', repos = c('https://glycoverse.r-universe.dev', 'https://cloud.r-project.org')) |
Bug tracker:https://github.com/glycoverse/glyclean/issues
Pkgdown/docs site:https://glycoverse.github.io
Last updated from:d10d13d69b (on v0.14.1). Checks:9 OK. Indexed: yes.
| Target | Result | Time | Files | Syslog |
|---|---|---|---|---|
| linux-devel-x86_64 | OK | 252 | ||
| source / vignettes | OK | 400 | ||
| linux-release-x86_64 | OK | 256 | ||
| macos-release-arm64 | OK | 127 | ||
| macos-oldrel-arm64 | OK | 116 | ||
| windows-devel | OK | 186 | ||
| windows-release | OK | 202 | ||
| windows-oldrel | OK | 170 | ||
| wasm-release | OK | 178 |
Exports:add_site_seqadjust_proteinaggregateauto_aggregateauto_cleanauto_codaauto_correct_batch_effectauto_imputeauto_normalizeauto_removecorrect_batch_effectdetect_batch_effectimpute_bpcaimpute_fw_knnimpute_half_sample_minimpute_min_probimpute_miss_forestimpute_ppcaimpute_sample_minimpute_svdimpute_sw_knnimpute_zeronormalize_loesscycnormalize_loessfnormalize_mediannormalize_median_absnormalize_median_quotientnormalize_quantilenormalize_rlrnormalize_rlrmanormalize_rlrmacycnormalize_total_areanormalize_vsnplot_batch_pcaplot_cv_dentplot_int_boxplotplot_missing_barplot_missing_heatmapplot_rank_abundanceplot_rep_scatterplot_rleplot_tic_barremove_constantremove_low_cvremove_low_exprremove_low_varremove_raretransform_alrtransform_clr
Dependencies:ade4annotateAnnotationDbiaskpassbackportsBHBiobaseBiocBaseUtilsBiocFileCacheBiocGenericsBiocParallelBiostringsbitbit64blobcachemcheckmateclicodetoolscpp11crayoncurlDBIdbplyrdigestdoRNGdplyredgeRfarverfastmapfilelockforcatsforeachformatRfurrrfutile.loggerfutile.optionsfuturegenefiltergenericsggplot2globalsglueglyexpglyreprgtablehmshttrhttr2igraphIRangesisobanditeratorsitertoolsjsonliteKEGGRESTlabelinglambda.rlatticelifecyclelimmalistenvlocfitmagrittrMASSMatrixMatrixGenericsmatrixStatsmemoisemgcvmimemissForestnlmeopensslparallellypcaMethodspillarpixmappkgconfigpngprettyunitsprogresspurrrR6randomForestrangerrappdirsrbibutilsRColorBrewerRcppRcppArmadilloRcppEigenRdpackrjsonconsrlangrngtoolsRSQLiterstackdequeS4VectorsS7scalessegmentedSeqinfoseqinrsnowspstatmodstringistringrsurvivalsvasystibbletidyrtidyselectUniProt.wsutf8vctrsviridisLitewithrXMLxtableXVector
Readme and manuals
Help Manual
| Help page | Topics |
|---|---|
| Add site-specific sequence information. | add_site_seq add_site_seq.default add_site_seq.glyexp_experiment |
| Adjust Protein Expression | adjust_protein adjust_protein.default adjust_protein.glyexp_experiment |
| Aggregate Data | aggregate glyclean_aggregate.default glyclean_aggregate.glyexp_experiment |
| Automatic Aggregation | auto_aggregate |
| Automatic Data Preprocessing | auto_clean |
| Automatical CoDA transformation | auto_coda |
| Automatic Batch Correction | auto_correct_batch_effect |
| Automatic Imputation | auto_impute |
| Automatic Normalization | auto_normalize |
| Automatic Removing Variables | auto_remove |
| Correct Batch Effect | correct_batch_effect correct_batch_effect.default correct_batch_effect.glyexp_experiment correct_batch_effect.matrix |
| Detect batch effect | detect_batch_effect detect_batch_effect.default detect_batch_effect.glyexp_experiment detect_batch_effect.matrix |
| BPCA Imputation | impute_bpca impute_bpca.default impute_bpca.glyexp_experiment impute_bpca.matrix |
| Feature-wise KNN Imputation | impute_fw_knn impute_fw_knn.default impute_fw_knn.glyexp_experiment impute_fw_knn.matrix |
| Half Sample Minimum Imputation | impute_half_sample_min impute_half_sample_min.default impute_half_sample_min.glyexp_experiment impute_half_sample_min.matrix |
| Minimum Probability Imputation | impute_min_prob impute_min_prob.default impute_min_prob.glyexp_experiment impute_min_prob.matrix |
| MissForest Imputation | impute_miss_forest impute_miss_forest.default impute_miss_forest.glyexp_experiment impute_miss_forest.matrix |
| PPCA Imputation | impute_ppca impute_ppca.default impute_ppca.glyexp_experiment impute_ppca.matrix |
| Sample Minimum Imputation | impute_sample_min impute_sample_min.default impute_sample_min.glyexp_experiment impute_sample_min.matrix |
| SVD Imputation | impute_svd impute_svd.default impute_svd.glyexp_experiment impute_svd.matrix |
| Sample-wise KNN Imputation | impute_sw_knn impute_sw_knn.default impute_sw_knn.glyexp_experiment impute_sw_knn.matrix |
| Zero Imputation | impute_zero impute_zero.default impute_zero.glyexp_experiment impute_zero.matrix |
| LoessCyc Normalization | normalize_loesscyc normalize_loesscyc.default normalize_loesscyc.glyexp_experiment normalize_loesscyc.matrix |
| LoessF Normalization | normalize_loessf normalize_loessf.default normalize_loessf.glyexp_experiment normalize_loessf.matrix |
| Median Normalization | normalize_median normalize_median.default normalize_median.glyexp_experiment normalize_median.matrix |
| Absolute Median Normalization | normalize_median_abs normalize_median_abs.default normalize_median_abs.glyexp_experiment normalize_median_abs.matrix |
| Median Quotient Normalization | normalize_median_quotient normalize_median_quotient.default normalize_median_quotient.glyexp_experiment normalize_median_quotient.matrix |
| Quantile Normalization | normalize_quantile normalize_quantile.default normalize_quantile.glyexp_experiment normalize_quantile.matrix |
| Robust Linear Regression Normalization | normalize_rlr normalize_rlr.default normalize_rlr.glyexp_experiment normalize_rlr.matrix |
| Robust Linear Regression with Median Adjustment Normalization | normalize_rlrma normalize_rlrma.default normalize_rlrma.glyexp_experiment normalize_rlrma.matrix |
| Robust Linear Regression with Median Adjustment and Cyclic Normalization | normalize_rlrmacyc normalize_rlrmacyc.default normalize_rlrmacyc.glyexp_experiment normalize_rlrmacyc.matrix |
| Total Area Normalization | normalize_total_area normalize_total_area.default normalize_total_area.glyexp_experiment normalize_total_area.matrix |
| Variance Stabilizing Normalization | normalize_vsn normalize_vsn.default normalize_vsn.glyexp_experiment normalize_vsn.matrix |
| Plot PCA Score by Batch | plot_batch_pca |
| Plot CV Density | plot_cv_dent |
| Plot Log-Intensity Boxplots by Sample | plot_int_boxplot |
| Plot Missing Value Proportions by Sample or Variable | plot_missing_bar |
| Plot Missing Value Heatmap | plot_missing_heatmap |
| Plot Rank Abundance | plot_rank_abundance |
| Plot Replicate Scatter Plots | plot_rep_scatter |
| Plot Relative Log Expression (RLE) Boxplots | plot_rle |
| Plot Total Intensity by Sample | plot_tic_bar |
| Remove Constant Variables | remove_constant |
| Remove Variables with Low Coefficient of Variation | remove_low_cv remove_low_cv.default remove_low_cv.glyexp_experiment remove_low_cv.matrix |
| Remove Variables with Low Expression | remove_low_expr remove_low_expr.default remove_low_expr.glyexp_experiment remove_low_expr.matrix |
| Remove Variables with Low Variance Remove Variables with Low Variance | remove_low_var remove_low_var.default remove_low_var.glyexp_experiment remove_low_var.matrix |
| Remove Rare Variables with Too Many Missing Values | remove_rare remove_rare.default remove_rare.glyexp_experiment remove_rare.matrix |
| Additive Log-Ratio Transformation | transform_alr transform_alr.default transform_alr.glyexp_experiment transform_alr.matrix |
| Centered Log-Ratio Transformation | transform_clr transform_clr.default transform_clr.glyexp_experiment transform_clr.matrix |