Package: glyenzy 0.10.0

glyenzy: Deconstruction Glycosylation Biosynthesis

Simulates the biosynthetic process of glycosylation in silico, enabling computational analysis of glycan biosynthesis pathways. Key features include: identifying specific glycosyltransferases responsible for each glycosidic bond at the bond level; reconstructing complete biosynthetic pathways for given glycans; exploring possible transformations between two glycan structures via glycosyltransferases, glycosidases, and sulfotransferases; and predicting glycans that can be synthesized from substrate structures and enzyme sets. The package supports multiple glycan types including N-glycans, O-GalNAc, O-Man, O-GlcNAc, O-Fuc, and O-Glc, selected glycosphingolipid headgroups, and sulfate modifications in canonical N- and O-glycan contexts. Lipid aglycones are not represented, so glycolipid rules model their carbohydrate headgroups with ceramide omitted. As a downstream component of the glycoverse ecosystem, it integrates seamlessly with 'glyrepr', 'glyparse', and 'glymotif' to provide practical, analysis-ready insights into glycan biosynthesis for omics researchers.

Authors:Bin Fu [aut, cre]